Mouse TNFSF13 Protein

11.12.2012

Sino Biological Inc. liefert Mouse TNFSF13 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse TNFSF13 Protein lesen Sie bitte: http://www.sinobiological.com/TNFSF13-Protein-g-9983.html

Product Information von TNFSF13 Protein

Synonym :	TNFSF13, April
Protein Construction:	A DNA sequence encoding the mouse TNFSF13(Q9D777)(Ala96-Leu240) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Source:	Mouse
Expression Host:	Human Cells

QC Testing von TNFSF13 Protein

Purity:	> 95 % as determined by SDS-PAGE	SDS-PAGE: TNFSF13 protein
Endotoxin:	< 1.0 EU per μg of the protein as determined by the LAL method
Stability:	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal:	Glu
Molecular Mass:	The recombinant mouse TNFSF13/Fc comprises 405 amino acids and has a predicted molecular mass of 44.8 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation:	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFSF13 Protein

Storage:	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TNFSF13 Protein

TNFSF13 belongs to the tumor necrosis factor (TNF) ligand family. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T- and B-cell regulatory effects. It also possesses a heparin binding domain and has been demonstrated to bind to proteoglycans on the cell surface. TNFSF13 is a potential biomarker, with serum levels elevated for certain cancers and expression levels elevated in cancer tissues. It is also a potential biomarker for certain autoimmune diseases.

References

Bossen C. et al., 2007, Immunol. 18 (5): 263-75.
Tangye SG. et al., 2007, Immunol. 18 (5): 305-17.
Osman W. et al., 2012, PLoS One. 7 (4): e32683.