CANX / Calnexin Protein

11.12.2012

Sino Biological Inc. liefert CANX / Calnexin Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CANX / Calnexin Protein lesen Sie bitte: http://www.sinobiological.com/CANX-Calnexin-Protein-g-9982.html

Produkt-Information von CANX / Calnexin Protein

Synonym	CANX
Protein Construction	A DNA sequence encoding the human CANX (P27824)(Met1-Pro481) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von CANX / Calnexin Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: CANX protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His 21
Molecular Mass	The recombinant human CANX/Fc is a disulfide-linked homodimer. The reduced monomer comprises 702 amino acids and has a predicted molecular mass of 79.4 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CANX / Calnexin Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CANX / Calnexin Protein

Calnexin belongs to the calreticulin family. It is a calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. It seems that calnexin affects the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally calnexin may play a role in receptor-mediated endocytosis at the synapse.

References

Rajagopalan S. et al., 1994, Science. 263 (5145): 387-90.
Lenter M. et al., 1994, J Biol Chem. 269 (16): 12263-8.
Pind S. et al., 1994, Science. 263 (5145): 387-90.