Mouse TLR2 Protein (His Tag)

Produkt-Information von TLR2 Protein

QC Testing von TLR2 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: TLR2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 25
Molecular Mass	The recombinant mouse TLR2 consists of 573 amino acids and has a calculated molecular mass of 64.8 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH7.4, 10%gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TLR2 Protein

Verwandte Produkte & Themen von TLR2 Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>> TLR2  / CD282

Beschreibung von TLR2 Protein

TLR2, also known as CD282, belongs to the Toll-like receptor (TLR) family. Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like receptors are activated by molecules associated with biological threat and are highly specific towards evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella and unmethylated CpG islands. TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. It is also detected in lung and in fetal liver. Levels are low in other tissues. TLR2 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It also cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. TLR2 may also promote apoptosis in response to lipoproteins. CD282 recognizes mycoplasmal macrophage-activating lipopeptide-2kD, soluble tuberculosis factor, phenol-soluble modulin and B.burgdorferi outer surface protein A lipoprotein cooperatively with TLR6.

References

1. Do KN. et al., 2012, PLoS ONE. 7 (3): e32309.
2. Dziarski R. et al., 2001, J Endotoxin Res. 6( 5): 401-5.
3. Lorenz E. 2007, Curr Pharm Des. 12 (32): 4185-93.

Sino Biological Inc. liefert Mouse TLR2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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