Mouse CDH6 / KCAD Protein (His Tag)

Produkt-Information von CDH6 / KCAD Protein

QC Testing von CDH6 / KCAD Protein

Purity	>90% as determined by SDS-PAGE	SDS-PAGE: CDH6 / KCAD protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Thr 19
Molecular Mass	The recombinant mouse CDH6 comprises 616 amino acids and has a predicted molecular mass of 68.7 kDa. The apparent molecular mass of the protein is approximately 98 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CDH6 / KCAD Protein

Verwandte Produkte & Themen von CDH6 / KCAD Protein

Immunology>>Adhesion Molecule>> Cadherin>>Cadherin-6/K-Cadherin/CDH6

Beschreibung von CDH6 / KCAD Protein

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. Cadherin-6(CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human cadherin-6 is synthesized as a 790 aa type I  transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa.

References

1. Nakagawa Y. et al., 1999, J Neurosci. 19: 10877-85.
2. Shimazui T. et al., 2000, Eur Urol. 38: 331-8.
3. Suzuki SC. et al., 1997, Mol Cell Neurosci. 9: 433-47.
4. Inoue T. et al., 1997, Dev Biol. 183: 183-94.

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