Mouse PLAT Protein

12.09.2012

Produkt-Information von PLAT Protein

Synonym	PLAT
Protein Construction	A DNA sequence encoding the mouse PLAT (P11214) (Ile309-Gln559) was was expressed with the fused Fc region of human IgG1 at the N-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von PLAT Protein

Purity	> 80 % as determined by SDS-PAGE	SDS-PAGE: PLAT protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant mouse PLAT/Fc comprises 511 amino acids and has a predicted molecular mass of 56.4 kDa. The apparent molecular mass of the protein is approximately 57kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS,pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PLAT Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PLAT Protein

PLAT, also known as plasminogen activator and tissue plasminogen activator, is a member of the peptidase S1 family. It is a heterodimer of chain A and chain B held by a disulfide bond. PLAT contains 1 EGF-like domain, 1 fibronectin type-I domain and 2 kringle domains. It is synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk. PLAT forms heterodimer with SERPINA5. It binds to fibrin with high affinity. It also binds to annexin A2, cytokeratin-8, fibronectin and laminin. Increased activity of plasminogen activator results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of plasminogen activator results in hypofibrinolysis that can lead to thrombosis or embolism.

References

Zhuo M. et al., 2000, J eurosci. 20 (2): 542-9.
Ichinose A. et al., 1986, J Clin Invest. 78 (1): 163-9.
Mateen FJ. et al., 2009, Mayo Clin Proceedings. 84 (4): 384-8.

Sino Biological Inc. liefert Mouse PLAT Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse PLAT Protein lesen Sie bitte: http://www.sinobiological.com/PLAT-Protein-g-9244.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
tPA/PLAT	Human	PLAT / tPA Protein, Recombinant	10157-H01H1
tPA/PLAT	Human	tPAβ /Fc Protein, Recombinant	10157-H01H2
tPA/PLAT	Human	tPAβ Protein, Recombinant	10157-HNCH2
tPA/PLAT	Mouse	PLAT Protein, Recombinant	50910-M01H1