Mouse ApoA1 Protein (His Tag)

Produkt-Information von ApoA1 Protein

QC Testing von ApoA1 Protein

Purity	>94% as determined by SDS-PAGE	SDS-PAGE: ApoA1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Trp 19
Molecular Mass	The recombinant mouse ApoA1 comprises 257 amino acids and has a predicted molecular mass of 30.2 kDa. The apparent molecular mass of the protein is approximately 27-31 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA..

Usage Guide von ApoA1 Protein

Verwandte Produkte & Themen von ApoA1 Protein

Cardiovascular>>Lipid Metabolism>>ApoA1

Beschreibung von ApoA1 Protein

Apolipoprotein A1 (APOA1) is the main component of high density lipoprotein (HDL) in plasma and is involved in the esterification of cholesterol as a cofactor of lecithin-cholesterol acyltransferase(LCAT) which is responsible for the formation of most plasma cholesteryl esters. and thus play a major role in cholesterol efflux from peripheral cells. APOA1 is also characterized as a prostacyclin stabilizing factor, and thus may have an anticlotting effect. Defects in encoding gene may result in HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. As a major component of the HDL complex, APOA1 helps to clear cholesterol from arteries. Men carrying a mutation may develop premature coronary artery disease.

References

1. Toptas B. et al., 2011, In Vivo. 25 (3): 425-30.
2. Haase CL. et al., 2011, J Intern Med. 270 (2): 136-46.
3. Wu Z. et al., 2011, J Biol Chem. 286 (14): 12495-508.

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