Mouse PGF / PIGF / PLGF Protein

26.04.2013

Sino Biological Inc. liefert Mouse PGF / PIGF / PLGF Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse PGF / PIGF / PLGF Protein lesen Sie bitte: http://www.sinobiological.com/PIGF-PLGF-Protein-a-2572.html

Produkt-Information von PGF / PIGF / PLGF Protein

Synonym	PGF, Plgf
Protein Construction	A DNA sequence encoding the mouse PGF (P49764) (Met1-Pro158) was fused with five amino acids (DDDDK) at the C- terminus was expressed and purified.
Source	Mouse
Expression Host	Human Cells

QC Testing von PGF / PIGF / PLGF Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: PGF protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 19
Molecular Mass	The recombinant mouse PGF consists of 146 amino acids and has a calculated molecular mass of 16.6 kDa. The recombinant protein migrates as an approximately 28 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von PGF / PIGF / PLGF Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PGF / PIGF / PLGF Protein

Placental growth factor (PlGF, PLGF, PGF), and its receptor VEGFR-1 (Flt-1) constitute potential candidates for therapeutic modulation of angiogenesis and inflammation. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PlGF/PLGF is an angiogenic factor that belongs to the vascular endothelial growth factor (VEGF) family. Besides inducing its own signaling in endothelial cells, PlGF exerts its angiogenic action by synergising with VEGF. In the skin, PlGF expression is upregulated during wound healing and PlGF-deficient mice show delayed wound closure, indicating that this factor promotes angiogenesis during skin repair. Moreover, PlGF expression by melanoma cells has been linked to tumor growth.

References

Khalil A. et al., 2008, PLoS ONE. 3 (7): e2766.
Luttun A. 2002, Ann N Y Acad Sci. 979: 80-93.
Chaballe L. et al., 2011, Acta Neurol Belg. 111 (1): 10-7.
Odorisio T. et al., 2006, J Dermatol Sci. 41 (1): 11-9.

PGF (PIGF) related areas, pathways, and other information