Mouse NXPH1 / Neurexophilin-1 Protein (His Tag)

Sino Biological Inc. liefert Mouse NXPH1 / Neurexophilin-1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von NXPH1 / Neurexophilin-1 Protein

QC Testing von NXPH1 / Neurexophilin-1 Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: NXPH1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 22
Molecular Mass	The recombinant mouse NXPH1 comprises 261 amino acids and has a predicted molecular mass of 30.1 kDa. The apparent molecular mass of the protein is approximately 46-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von NXPH1 / Neurexophilin-1 Protein

Verwandte Produkte & Themen von NXPH1 / Neurexophilin-1 Protein

Neuroscience>>Synaptic Protein>>Neurexophilin-1/NXPH1

Beschreibung von NXPH1 / Neurexophilin-1 Protein

Neurexophilin-1 ( NXPH1 ) is a member of the neurexophilin family, this secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. Neurexophilin-1 protein is encoded by the NXPH1 gene, which has highest level in brain. It was discovered as a neuronal glycoprotein that is copurified with neurexin Ialpha during affinity chromatography on immobilized alpha-latrotoxin. Neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains. Neurexophilins 1 and 3 but not 4 bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins. Neurexophilin-1 may be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells. As a secreted cysteine-rich glycoprotein, Neurexophilin-1 is synthesized in a subclass of neurons, and may be signaling molecules that resemble neuropeptides.

References

1. Petrenko AG. et al., 1996, J Neurosci. 16(14): 4360-9.
2. Missler M. et al., 1998, J Biol Chem. 273(52): 34716-23.
3. Missler M. et al., 1998, J Neurosci. 18(10): 3630-8.