Mouse BAMBI / NMA Protein

13.12.2012

Sino Biological Inc. liefert Mouse BAMBI / NMA Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse BAMBI / NMA Protein lesen Sie bitte: http://www.sinobiological.com/BAMBI-NMA-Protein-g-9997.html

Produkt-Informationvon BAMBI / NMA Protein

Synonym	BAMBI, Nma
Protein Construction	A DNA sequence encoding the mouse BAMBI (Q9D0L6)(Met1-Ala152) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von BAMBI / NMA Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: BAMBI protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 27
Molecular Mass	The recombinant mouse BAMBI /Fc is a disulfide-linked homodimer. The reduced monomer comprises 367 amino acids and has a predicted molecular mass of 41 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von BAMBI / NMA Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von BAMBI / NMA Protein

Related Areas:

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>BAMBI/NMA

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>BAMBI/NMA

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Modulators>>BAMBI/NMA

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
BAMBI/NMA	Human	BAMBI/NMA Protein, Recombinant	10890-H08H
BAMBI/NMA	Mouse	BAMBI Protein, Recombinant	50895-M02H
BAMBI/NMA	Mouse	BAMBI Protein, Recombinant	50895-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human BAMBI/NMA	WB	BAMBI/NMA Antibody, Mouse MAb	10890-MM04
Human BAMBI/NMA	ELISA	BAMBI/NMA Antibody, Mouse MAb	10890-MM06
Human BAMBI/NMA	WB, ELISA	BAMBI/NMA Antibody, Rabbit PAb	10890-RP01
Human BAMBI/NMA	WB, ELISA	BAMBI/NMA Antibody, Rabbit PAb (Antigen Affinity Purified)	10890-RP02
Human BAMBI/NMA	WB, ELISA	BAMBI / NMA Antibody	10890-R211

BAMBI / NMA Protein

BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor- beta(TGF- beta) , through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta- catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

References

Sekiya T. et al. 2003, The Journal of Biological Chemistry. 279: 6840-6.
Shi YG. et al. 2003, Cell. 113 (6): 685-700.
Wanninger J. et al. 2011, FEBS Lett. 585 (9): 1338-44.