Mouse MANF / ARMET Protein (His Tag)

Produkt-Information von MANF / ARMET Protein

QC Testing von MANF / ARMET Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: MANF / ARMET protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 22
Molecular Mass	The secreted recombinant mouse MANF comprises 169 amino acids and has a calculated molecular mass of 19.6 kDa. The apparent molecular mass of the recombinant protein is approximately 21 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

MANF / ARMET Protein Usage Guide

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Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>MANF/ARMET

Beschreibung von MANF / ARMET Protein

Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF and ARMET, is a secreted protein which belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

References

1. Shridhar V., et al., 1996, Oncogene 12:1931-1939.
2. Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569.
3. Petrova P., et al., 2003, J. Mol. Neurosci. 20:173-188.
4. Lindholm, P. et al., 2008, Mol Cell Neurosci. 39 (3):356-71.
5. Airavaara, M. et al., 2010, Exp Neurol. 225 (1):104-13.

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