Mouse IL21 / Interleukin 21 Protein (Native)

Produkt-Information von IL21 / Interleukin 21 Protein

QC Testing von IL21 / Interleukin 21 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: IL21 / Interleukin 21 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse IL21 consists of 123 amino acids and has a calculated molecular mass of 14.3KDa. It migrates as a 15 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH 7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL21 / Interleukin 21 Protein

Verwandte Produkte & Themen von IL21 / Interleukin 21 Protein

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-21/IL21

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-21/IL21

Beschreibung von IL21 / Interleukin 21 Protein

IL21 is a cytokine with immunoregulatory activity. It is a member of the IL-15/IL-21 family. It is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. IL21 may promote the transition between innate and adaptive immunity. It induces the production of IgG(1) and IgG(3) in B-cells (By similarity). IL21 may also play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. The proliferation of mature B- and T-cells in response to activating stimuli may be regulated by IL21. In synergy with IL15 and IL18, IL21 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response it may inhibit dendritic cells (DC) activation and maturation. Systemic treatment of IL-21 may be an effective means of mitigating the allergic response. IL-21 also may be a critical factor in the control of persistent viral infections.

References

1. Coquet JM. et al., 2007, J Immunol. 178 (5): 2827-34.
2. Wei L. et al., 2007, J Biol Chem. 282 (48): 34605-10.
3. Parrish-Novak J. et al., 2002, J Leukoc Biol. 72 (5): 856-63.
4. Kuchen S. et al., 2007, J Immunol. 179 (9): 5886-96.

Sino Biological Inc. liefert Mouse IL21 / Interleukin 21 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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