Mouse FAM3D / Oit1 Protein (His Tag)

Sino Biological Inc. liefert Mouse FAM3D / Oit1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von FAM3D / Oit1 Protein

QC Testing von FAM3D / Oit1 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: FAM3D protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Thr 26
Molecular Mass	The recombinant mouse FAM3D comprises 209 amino acids and has a predicted molecular mass of 23.5 kDa. The apparent molecular mass of the protein is approximately 23 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FAM3D / Oit1 Protein

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Beschreibung von FAM3D / Oit1 Protein

Family with sequence similarity 3 (FAM3) family is a novel cytokine-like family. There are four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. It had indicated that FAM3B/PANDER (pancreatic derived factor) is highly expressed in pancreas, and FAM3A and FAM3C in almost all tissues. FAM3D is abundantly expressed in placenta and weakly expressed in small intestine. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. FAM3A and FAM3B protein were both localized to the islets of Langerhans of the endocrine pancreas. Recombinant FAM3B protein has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner. FAM3C is involved in retinal laminar formation processes in vertebrates. NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. Some of these associations were further supported by gene expression analyses and an association study in essential hypersomnia (EHS), CNS hypersonia similar to narcolepsy.

References

1. Zhu Y. et al., 2002, Genomics. 80(2): 144-50.
2. Katahira T. et al.,2010, Biochem Biophys Res Commun. 392 (3): 301-6.
3. Shimada M. et al., 2010, Hum Genet. 128(4): 433-41.