Mouse Cystatin-F / CST7 / Cystatin-7 Protein

Produkt-Information von Cystatin-F / CST7 / Cystatin-7 Protein

QC Testing von Cystatin-F / CST7 / Cystatin-7 Protein

Purity	> 93 % as determined by SDS-PAGE	SDS-PAGE: Cystatin-F / CST7 / Cystatin-7 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 19
Molecular Mass	The recombinant mouse CST7 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 367 amino acids and has a predicted molecular mass of 41.4 KDa. The apparent molecular mass of the protein is approximately 42 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of 25mMTris,0.15MNaCl,pH7.5 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Cystatin-F / CST7 / Cystatin-7 Protein

Verwandte Produkte & Themen von Cystatin-F / CST7 / Cystatin-7 Protein

Enzyme>>Protease & Regulator>>Cysteine Protease & Regulator>>Cystatin>>Cystatin F/CST7

Cancer>>Angiogenesis>>Cystatin>>Cystatin F/CST7

Beschreibung von Cystatin-F / CST7 / Cystatin-7 Protein

The cystatin superfamily members are important natural cysteine protease inhibitors present in a wide variety of organisms and are divided into three classes. Cystatin F, also known as leukocystatin and CMAP (Cystatin-like Metastasis-Associated Protein), is a type 2 cystatin and its expression is limited to hematopoietic cells, with the highest expression levels being observed in monocytes, dendritic cells, and certain types of T-cells. Furthermore, cystatin F mRNA becomes up-regulated during dendritic cell maturation, and thus suggests a specific role of cystatin F in immune regulation. Cystatin F is produced as a dimer, an inactive cathepsin inhibitor which is activated by chemical reduction. In addition, Cystatin F and its homologues have been observed expressing in various human cancer cell lines established from malignant tumors, and thus indicates a new diagnosis and prevention approach of certain human carcinomas metastasis.

References

1. Ni J. et al., 1998, J Biol Chem. 273: 24797-804.
2. Morita M. et al., 1999, Cancer Res. 59:151–8.
3. Langerholc T. et al., 2005, FEBS J. 272: 1535-45.
4. Hamilton G. et al., 2008, EMBO J. 27: 499-508.
5. Alexander W. et al., 2006, J Biol Chem. 281: 16570-5.

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