Mouse CLEC3B / Tetranectin Protein (His Tag)

Produkt-Information CLEC3B / Tetranectin Protein

QC Testing von CLEC3B / Tetranectin Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CLEC3B / Tetranectin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 22
Molecular Mass	The recombinant mouse CLEC3B consists of 188 amino acids and predicts a molecular mass of 20.7 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCLEC3B is approximately 25 KDa.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CLEC3B / Tetranectin Protein

Verwandte Produkte & Themen von CLEC3B / Tetranectin Protein

Immunology>>Adhesion Molecule>>Lectin>>Tetranectin/CLEC3B

Beschreibung von CLEC3B / Tetranectin Protein

Tetranectin, also known as C-type lectin domain family 3, member B (CLEC3B), is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin. In terms of primary and tertiary structure, Tetranectin is related to the collectin family of Ca(2+)-binding C-type lectins. Tetranectin is encoded in three exons. Exon 3 encodes the carbohydrate recognition domain, which binds to kringle 4 in plasminogen at low levels of Ca(2+). Exon 2 encodes an alpha-helix, which is necessary and sufficient to govern the trimerization of Tetranectin by assembling into a triple-helical coiled-coil structural element. Tetranectin has been suggested to play a role in tissue remodeling, due to its ability to stimulate plasminogen activation and its expression in developing tissues such as developing bone and muscle. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. TN may play a role in neurological diseases and may serve as a diagnostic aid in multiple sclerosis (MS). The serum or saliva Tetranectin may serve as a potential biomarker for metastatic oral squamous cell carcinoma (OSCC). Decreased plasma Tetranectin or increased Tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis.

References

1. Lorentsen RH. et al., 2000, Biochem J. 347 (1): 83-7.
2. Iba K. et al., 2001, Mol Cell Biol. 21 (22): 7817-25.
3. Iba K. et al., 2009, Wound Repair Regen. 17 (1): 108-12.
4. Stoevring B. et al., 2006, Scand J Clin Lab Invest. 66 (7): 577-83.
5. Arellano-Garcia ME. et al., 2010, Int J Mol Sci. 11 (9): 3106-21.
6. Mogues T. et al., 2004, J Biomed Biotechnol. 2004 (2): 73-8.

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