MAP2K6 / MKK6 / MEK6 Protein

Sino Biological Inc. liefert MAP2K6 / MKK6 / MEK6 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über MAP2K6 / MKK6 / MEK6 Protein lesen Sie bitte: http://www.sinobiological.com/MKK6-MEK6-MAP2K6-Protein-a-2442.html

Produkt-Information von MAP2K6 / MKK6 / MEK6 Protein

QC Testing von MAP2K6 / MKK6 / MEK6 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: MKK6 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly
Molecular Mass	The secreted recombinant human MKK6 consists of 336 amino acids and predicts a molecular mass of 37.6 KDa. The apparent molecular mass of the protein is approximately 37 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von MAP2K6 / MKK6 / MEK6 Protein

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Beschreibung von MAP2K6 / MKK6 / MEK6 Protein

Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6 and MKK6, is a protein which belongs to the?protein kinase superfamily, STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one?protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light, and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.

References

1. Stein B. et al., 1996, J Biol Chem. 271: 11427-33.
2. Han J. et al., 1996, J Biol Chem. 271: 2886-91.
3. Moriguchi T. et al., 1996, J Biol Chem. 271: 13675-9.
4. Oppermann FS. et al., 2009, Mol Cell Proteomics. 8: 1751-64.
5. Choudhary C. et al., 2009, Science. 325: 834-40.