LRPAP1 Antikörper

28.02.2012

Produkt-Information von LRPAP1 Antikörper

Immunogen	Recombinant Mouse LRPAP1 protein (Catalog#50281-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse LRPAP1 (rM LRPAP1;Catalog#50281-M08H; NP_038615.2; Gln 29-Leu 360). Total IgG was purified by Protein A affinity chromatography.

LRPAP1 Antikörper Usage Guide

Specificity	Mouse LRPAP1
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse LRPAP1 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse LRPAP1 . The detection limit for Mouse LRPAP1 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Podukte & Themen von LRPAP1 Antikörper

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Hintergrund von LRPAP1 Antikörper

Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. LRPAP1 is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330), and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of thethyroid, where it can serve as a receptor for the proteinthyroglobulin.

References

Liu, CX. et al., 2001, J. Biol. Chem. 276: 28889-96.
Schutte DL, et al., 2003,Res Theory Nurs Pract.17 (4): 301-19.
Jensen, GA. et al., 2006, J. Mol. Biol. 362: 700-16.
Santovito, A. et al., 2007, Hum Biol. 79 (6): 699-706.

Sino Biological Inc. liefert LRPAP1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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