LILRA3 / ILT6 Protein

10.12.2012

Sino Biological Inc. liefert LILRA3 / ILT6 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über LILRA3 / ILT6 Protein lesen Sie bitte: http://www.sinobiological.com/LILRA3-ILT6-Protein-g-9977.html

Produkt-Information von LILRA3 / ILT6 Protein

Synonym	LILRA3, ILT6, LIR4
Protein Construction	A DNA sequence encoding the human LILRA3 (AAH28208.1)(Met1-Glu439) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von LILRA3 / ILT6 Protein

Purity	> 80 % as determined by SDS-PAGE	SDS-PAGE: LILRA3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 24
Molecular Mass	The recombinant human LILRA3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 657 amino acids and has a predicted molecular mass of 72 kDa. The apparent molecular mass of the protein is approximately 102 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von LILRA3 / ILT6 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von LILRA3 / ILT6 Protein

ILT6 is a member of the ILT family. ILT family proteins are expressed predominantly on myeloid lineage cells, and some members have been shown to bind classical (HLA-A and -B) and non-classical (HLA-G1, -E and -F) MHC class I molecules. Several nomenclatures exist, giving each member a different ILT, LIR, LILR, CD85 or other designation. ILT6 contains 4 Ig-like C2-type (immunoglobulin-like) domains and may act as soluble receptor for class I MHC antigens. It can be detected n B-cells, and at lower levels in natural killer (NK) cells. Unlike many of its family, ILT6 lacks a transmembrane domain. If secreted, the ILT6 might impair interactions of membrane-bound LILRs with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

References

Wi?niewski A. et al., 2004, Hum Immunol. 64 (4): 458-61.
Norman PJ. et al., 2003, Immunogenetics. 55 (3): 165-71.
Cella M. et al., 1997, J Exp Med. 185 (10): 1743-51.