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| Immunogen | Recombinant Mouse LIFR protein (Catalog#50423-M08H) |
| Antibody Type | Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) |
| Clone ID | 110 |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LIFR (rM LIFR; Catalog#50423-M08H; NP_038612.1; Met 1-Ser 828). |
| Specificity | Mouse LIFR |
| No cross-reactivity in ELISA with Human LIFR | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse LIFR in WB. Using a DAB detection system, the detection limit for Mouse LIFR is approximately 5 ng/lane under non-reducing conditions. |
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse LIFR. The detection limit for Mouse LIFR is approximately 0.0195 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Leukemia inhibitory factor receptor alpha (LIFR), also known as CD118, is the receptor for leukemia inhibitory factor (LIF), a pleiotropic cytokine affecting the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an α subunit that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex. The gp130 subunit was first described as the signal transducing subunit of the high-affinity IL-6 receptor complex. Human LIFRα subunit is a 1097 aa type I membrane protein with a 44 aa residue signal peptide, a 789 aa residue extracellular domain including two cytokine receptor domains and three fibronectin type III repeats, a 26 aa residue transmembrane domain, and a 238 aa residue cytoplasmic domain. Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.
Sino Biological Inc. liefert LIFR / CD118 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über LIFR / CD118 Antikörper lesen Sie bitte: http://www.sinobiological.com/LIFR-CD118-Antibody-g-9050.html
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