LDLR / LDL Receptor Antikörper ( FITC )

Sino Biological Inc. liefert LDLR / LDL Receptor Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über LDLR / LDL Receptor Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/LDLR-LDL-Receptor-Antibody-g-10070.html

Produkt-Information von LDLR / LDL Receptor Antikörper

Usage Guide von LDLR / LDL Receptor Antikörper

Specificity	Mouse LDLR / LDL Receptor
Flow Cytometry	Profile of anti-LDLR reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) prior to staining, washed, then stained with FITC Rabbit anti-LDLR. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von LDLR / LDL Receptor Antikörper

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>LDL Receptor

Cardiovascular>>Lipid Metabolism>>LDL Receptor

Hintergrund von LDLR / LDL Receptor Antikörper

Low-density lipoprotein (LDL) is a type of lipoprotein that transports cholesterol and triglycerides from the liver to peripheral tissues, and enables fats and cholesterol to move within the water-based solution of the blood stream. The Low-Density Lipoprotein Receptor (LDLR) is the prototype member of the LDLR family of scavenger receptors which is involved in receptor-mediated endocytosis of specific ligands. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. LDLR recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles, as well as the apoE protein found in chylomicron remnants and VLDL remnants (IDL). After taken into the cell ending up in lysosomes, LDL is degraded and the cholesterol is made available for repression of microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. As a mosaic protein, the extracellular region of LDLR consists of seven N-terminal complement-like cysteinerich repeats followed by three EGF like repeats with a β-propeller YWTD containing motif, and a membrane proximal Ser/Thr rich region. Furthermore, it is reported that in case of HIV-1 infection, LDLR functions as a receptor for extracellular Tat (HIV-1 transactivator) into neurons, mediating its internalization in uninfected cells. Mutations in LDLR gene cause the autosomal dominant disorder, familial hypercholesterolemia.

References

1. Suedhof, T.C. et al., 1985, Science. 228: 815-822.
2. Hobbs, H.H. et al., 1993, Hum. Mutat. 1: 445-466.
3. Barrett, P.H. and Watts, G.F. 2002, Atherosclerosis. Supplements. 2: 1-4.
4. Liu, Y. et al., 2000, Nat. Med. 6: 1380-1387.
5. Nomura, S. et al., 2004, Gene. Therapy. 11: 1540-1548.

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