4-1BBL / CD137L / TNFSF9 Antikörper ( FITC )

Sino Biological Inc. liefert 4-1BBL / CD137L / TNFSF9 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über 4-1BBL / CD137L / TNFSF9 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/4-1BBL-CD137L-TNFSF9-Antibody-g-10071.html

Produkt-Information von 4-1BBL / CD137L / TNFSF9 Antikörper

Usage Guide von 4-1BBL / CD137L / TNFSF9 Antikörper

Specificity	Mouse 4-1BBL / CD137L / TNFSF9
Flow Cytometry	Profile of anti-TNFSF9 reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) prior to staining, washed, then stained with FITC Rabbit anti-TNFSF9. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von 4-1BBL / CD137L / TNFSF9 Antikörper

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>4-1BBL/CD137L/TNFSF9

Immunology>>Cytokine & Receptor>>TNF Superfamily>>4-1BBL/CD137L/TNFSF9

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>4-1BBL/CD137L/TNFSF9

Hintergrund von 4-1BBL / CD137L / TNFSF9 Antikörper

4-1BB ligand (4-1BBL), also known as TNFSF9, is a member of the tumor necrosis factor (TNF) superfamily (TNFSF), and interacts with 4-1BB (CDw137) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth. Mouse 4-1BBL is a 309 amino acid (aa) residues protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that other TNFSF members, but shares only low aa sequence homology (14 - 16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart which is detected in both T and B cells of human peripheral blood. 4-1BB ligand interacts with 4-1BB and co-stimulates the latter to secrete cytokines and to proliferate, and also this interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in colitis without affecting regulatory T cell function.

References

1. Goodwin, R.G. et al., 1993, Eur. J. Immunol. 23: 2631-2641.
2. Alderson, M.R. et al., 1994, Eur. J. Immunol. 24: 2219-2227.
3. Zhou, Z.et al., 1995, Immunol. Lett. 45 (1-2): 67-73.
4. Futagawa, T. et al., 2002, Int Immunol. 14 (3): 275-286.
5. Yoshida,H. et al., 2003, Cancer Immunol Immunother.52 (2): 97-106.
6. Maerten, P. et al., 2006, Clin Exp Immunol.143 (2): 228-236.

Primary Antibody Products