Latexin / LXN Antikörper (Antigen Affinität reinigt)

23.02.2012

Produkt-Information von Latexin / LXN Antikörper

Immunogen	Recombinant Mouse Latexin / LXN protein (Catalog#50050-M07E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse Latexin / LXN (rM Latexin / LXN; Catalog#50050-M07E; NP_058033.2; Glu 2-Glu 222). Latexin / LXN specific IgG was purified by Mouse Latexin / LXN affinity chromatography.

Latexin / LXN Antikörper Usage Guide

Specificity	Mouse Latexin / LXN
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse LXN in WB. Using a DAB detection system, the detection limit for Mouse LXN is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse LXN. The detection limit for Mouse LXN is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Latexin / LXN Antikörper

Latexin, also known as tissue or endogenous carboxypeptidase inhibitor (TCI or ECI), is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.

References

Liu, Q. et al., 2000, Mol. Biol. Rep. 27: 241-246.
Aagaard, A. et al., 2005, Structure 13: 309-317.
Pallares, I. et al., 2005, Proc. Natl. Acad. Sci. USA. 102: 3978-3983.

Sino Biological Inc. liefert Latexin / LXN Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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