KIAA0101 / p15 / PAF Protein (His Tag)

04.05.2012

Produkt-Information von KIAA0101 / p15 / PAF Protein

Synonym	KIAA0101,L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, p15(PAF), p15/PAF, p15PAF
Protein Construction	A DNA sequence encoding the human PAF isoform 1(NP_055551.1) (Met 1-Glu 111) was expressed, with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von KIAA0101 / p15 / PAF Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: KIAA0101 / p15 / PAF protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human PAF consisting of 126 amino acids and has a calculated molecular mass of 13.8 KDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS; pH7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von KIAA0101 / p15 / PAF Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von KIAA0101 / p15 / PAF Protein

KIAA0101, also known as p15(PAF), is a proliferating cell nuclear antigen–associated factor and involved in cell proliferation. KIAA0101 was initially identified as a PCNA(proliferating cell nuclear antigen)-associated factor. It correlates with enhanced metastatic potential and is a significant prognostic factor of HCC(prognosis of hepatocellular carcinoma). Its expression was down-regulated in HCC. KIAA0101 is highly expressed in a number of tumors, specifically in esophageal tumors, anaplastic thyroid carcinomas, pancreatic cancer and non-small-cell lung cancer lines. KIAA0101 was also reported to be down-regulated in colon cancer cells and human hepatocellular carcinoma. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. KIAA0101 may contribute to growth advantage and resistance to hypoxic insult. It also may be involved in protection of cells from UV-induced cell death.

References

Yu P. et al., 2001, Oncogene. 20 (4): 484-9.
Simpson F. et al., 2005, Exp Cell Res. 312 (1): 73-85.
Guo M. et al., 2006, BMC Cancer. 6: 109.
Nagase T. et al., 1995, DNA Res. 2 (1): 37-43.

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