JNK2 / MAPK9 Antikörper

10.05.2012

Produkt-Information von JNK2 / MAPK9 Antikörper

Immunogen	Recombinant Human JNK2 / MAPK9 protein (Catalog#10745-H08B)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	011
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human JNK2 / MAPK9 (rh JNK2 / MAPK9; Catalog#10745-H08B; NP_002743.3; Met 1-Arg 424).

Usage Guide von JNK2 / MAPK9 Antikörper

Specificity

Human JNK2 / MAPK9

Immunochemistry

IHC-P: 1-10 μg/mL

MAPK9-brain immunohistochemistry MAPK9-kidney immunohistochemistry

Immunochemical staining of human MAPK9 in human brain with rabbit mnoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections).

Immunochemical staining of human MAPK9 in human kidney with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections).

Western blot

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human MAPK9 in WB.

Direct ELISA

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human MAPK9.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von JNK2 / MAPK9 Antikörper

Related Areas:

Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>JNK2/MAPK9

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Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
JNK2/MAPK9	Human	JNK2/MAPK9 Protein, Recombinant	10745-H08B

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human JNK2/MAPK9	WB, ELISA	JNK2/MAPK9 Antibody, Mouse MAb	10745-MM01
Human JNK2/MAPK9	WB, ELISA	JNK2/MAPK9 Antibody, Rabbit PAb	10745-RP01
Human JNK2/MAPK9	WB, ELISA	JNK2/MAPK9 Antibody, Rabbit PAb (Antigen Affinity Purified)	10745-RP02
Human JNK2/MAPK9	WB, ELISA	JNK2 / MAPK9 Antibody	10745-R004
Human JNK2/MAPK9	WB, ELISA, IHC-P	JNK2 / MAPK9 Antibody	10745-R011

Hintergrund von JNK2 / MAPK9 Antikörper

Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of MAP kinase subfamily belonging to the protein kinase superfamily. As an integration point for multiple biochemical signals, MAPKs are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, such as c-Jun and ATF2. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis. JNK protein kinases includes JNK1 and JNK2, and the activity of JNK2 was approximately 10-fold greater than that of JNK1 in c-Jun phosphorylation. JNK2 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Inaddition, JNK2 blocks the ubiquitination of tumor suppressor p53, and thus increases the stability of p53 in nonstressed cells. Several alternatively spliced transcript variants of JNK2 with different binding patterns have been identified: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

References

Sluss, H.K. et al., 1994, Mol. Cell. Biol. 14:8376-8384.
Kallunki, T. et al., 1994, Genes. Dev. 8: 2996-3007.
Gupta, S. 1996, EMBO. J. 15: 2760-2770.
Davis. R.J. 2000, Cell. 103: 239-252.

Sino Biological Inc. liefert JNK2 / MAPK9 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über JNK2 / MAPK9 Antikörper lesen Sie bitte: http://www.sinobiological.com/JNK2-MAPK9-Antibody-g-8781.html