IL20RA / IL-20RA Antikörper

09.05.2012

Produkt-Information von IL20RA / IL-20RA Antikörper

Immunogen	Recombinant Human IL20RA / IL-20RA protein (Catalog#10397-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	024
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human IL20RA / IL-20RA (rh IL20RA / IL-20RA; Catalog#10397-H08H; NP_055247.21; Met 1-Lys 250).

Usage Guide von IL20RA / IL-20RA Antikörper

Specificity

Human IL20RA / IL-20RA

No cross-reactivity in ELISA with

Human IFNgR1

Human IL10RB

Immunochemistry

IHC-P: 1-10 μg/mL

IL20Ra-skin immunohistochemistry

Immunochemical staining of human IL20Ra in human skin with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to stratified squamous epithelium.

Western blot

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL20Ra in WB.

Direct ELISA

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IL20Ra.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von IL20RA / IL-20RA Antikörper

Related Areas:

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL20RA/IL-20RA	Human	IL20RA/IL-20RA Protein, Recombinant	10397-H08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL20RA/IL-20RA	WB, ELISA	Mouse Monoclonal Antibody	10397-MM06
Human IL20RA/IL-20RA	ELISA	Rabbit Monoclonal Antibody	10397-R005
Human IL20RA/IL-20RA	WB, ELISA, IHC-P	IL20RA / IL-20RA Antibody	10397-R024
Human IL20RA/IL-20RA	WB	Rabbit Monoclonal Antibody	10397-R030
Human IL20RA/IL-20RA	WB, ELISA, IHC-P	IL20RA / IL-20RA Antibody	10397-R038
Human IL20RA/IL-20RA	WB, ELISA	Rabbit Monoclonal Antibody	10397-RP01
Human IL20RA/IL-20RA	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10397-RP02

Hintergrund von IL20RA / IL-20RA Antikörper

Interleukin 20 receptor, alpha (IL20Rα), also known as IL20RA and IL20R1, belongs to the type II cytokine receptor family, and contains two fibronectin type III domains. IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition,, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.

References

Dumoutier L. et al., 2001, J. Immunol. 167: 3545-3549.
Parrish-Novak J. et al., 2002, J. Biol. Chem. 277: 47517-47523.
Pletnev S. et al., 2003, Biochemistry. 42: 12617-12624.
Sheikh F. et al., 2004, J. Immunol. 172: 2006-2010.
Blumberg H. et al., 2001, Cell. 104: 9-19.

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