Mein Blog umfasst die aktuellesten News, Forschungsleistung, neuesten Produkte und Service von Sino Biological Inc. und die aktuelle News von Life Sciences. Sie können sich hier wissenschaftlich informieren.Willkommen zu meinem Blog.Viel Spaß!
| Immunogen | Recombinant Human IL18BP / IL18BPa protein (Catalog#10357-H08H) |
| Antibody Type | Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) |
| Clone ID | 224 |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL18BP / IL18BPa (rh IL18BP / IL18BPa ; Catalog#10357-H08H; NP_001034748.1; Met 1-Gly 192). |
| Specificity | Human IL18BP / IL18BPa |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL18BPa in WB. Using a DAB detection system, the detection limit for Human IL18BPa is approximately 5 ng/lane under reducing conditions and not recommended under non-reducing conditions. |
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL18BPa. The detection limit for Human IL18BPa is approximately 0.00975 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Interleukin 18 binding protein (IL18 BP) is a secreted glycoprotein which antagonizes the activity of the proinflammatory cytokine IL18 by binding to IL18 and blocking its biological activity. At least four isoforms differing in affinity for IL18 are produced from alternative splicing, and IL18 BP isoform a contains one immunoglobulin (Ig)-like C2-type domain. IL18 BPa binds IL18 with high affinity, prevents the binding of IL18 to its receptor, and thus inhibits the production of IFN- gamma, IL8, and activation of NF-kappa B, resulting in reduced T-helper type 1 (Th1) immune responses. IL18 BPa is constitutively expressed and secreted in mononuclear cells, and its expression can be induced and enhanced through the IFN- gamma-mediated pathway. The identified IFN-γ/ IL18 BPa negative feedback loop probably plays a key role in the modulation of both innate and adaptive immunity. A severe IL18/ IL18 BP imbalance is associated with hemophagocytic syndrome (HPS) characterized by an uncontrolled activation of Th-1 lymphocytes and macrophages. In addition, IL18 BPa is suggested to has a possible antimetastatic benefit, since IL18 plays a significant role in tumor hepatic metastasis.
Sino Biological Inc. liefert IL18BP / IL18BPa Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über IL18BP / IL18BPa Antikörper lesen Sie bitte: http:www.sinobiological.com/IL18BP-IL18BPa--Antibody-g-9192.html
/https%3A%2F%2Fassets.over-blog.com%2Ft%2Fcedistic%2Fcamera.png)