IL11 / Interleukin 11 / IL-11 Protein

03.05.2013

Sino Biological Inc. liefert IL11 / Interleukin 11 / IL-11 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über IL11 / Interleukin 11 / IL-11 Protein lesen Sie bitte: http://www.sinobiological.com/IL-11-interleukin-11-Protein-Antibody-a-5909.html

Produkt-Information von IL11 / Interleukin 11 / IL-11 Protein

Synonym	IL11
Protein Construction	A DNA sequence encoding the mature form of human IL11 (AAH12506.1) (Pro22-Leu199) was expressed.
Source	Human
Expression Host	E.coli

QC Testing von IL11 / Interleukin 11 / IL-11 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL11 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human IL11 consists of 178 amino acids and predicts a molecular mass of 19.1 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IL11 / Interleukin 11 / IL-11 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IL11 / Interleukin 11 / IL-11 Protein

IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.

References

McKinley D. et al., 1992, Genomics. 13 (3): 814-9.
Paul SR. et al., 1990, Proc Natl Acad Sci. 87 (19): 7512-6.
Kawashima I. et al., 1991, FEBS Lett. 283 (2): 199-202.