IL-1 beta Antikörper (Antigen Affinität reinigt)

13.03.2012

Produkt-Information von IL-1 beta Antikörper

Immunogen	Recombinant Mouse IL-1 beta protein (Catalog#50101-MNAE)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse IL-1 beta (rM IL-1 beta;Catalog#50101-MNAE; P10749; Val 118-Ser 269). IL-1 beta specific IgG was purified by Mouse IL-1 beta affinity chromatography.

IL-1 beta Antikörper Usage Guide

Specificity	Mouse IL-1 beta
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL-1 beta in WB. Using a DAB detection system, the detection limit for Mouse IL-1 beta is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL-1 beta. The detection limit for Mouse IL-1 beta is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von IL-1 beta Antikörper

Interleukin-1 beta, also known as IL-1 beta, and IL1B, is a secreted protein which belongs to the IL-1 family. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 / Interleukin-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 beta / IL1B is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1 / ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. IL-1 beta / IL1B is a potent pro-inflammatory cytokine. It is directly up-regulated by radiation and is known to regulate other inflammation-related molecules, such as the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs). IL-1 beta / IL1B plays a critical role in radiation-induced fibrosis and the increased MMPs fail to block the IL1-related collagen accumulation. The induction of cyclooxygenase-2 (PTGS2 / COX2) by IL-1 beta / IL1B in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.

References

Liu,W.et al., 2006, Radiat Res. 165 (2): 181-91.
Mattuzzi,S. et al., 2007, J Rheumatol. 34 (5): 997-1004.
Van Minkelen,R. 2007, et al., Arterioscler Thromb Vasc Biol. 27 (6): 1486-91.
Kim SH, et al.,2008, Mol. Vis. 14: 2109-16.
Levy,H. et al., 2009, Pediatr Pulmonol. 44 (6): 580-93.

Sino Biological Inc. liefert IL-1 beta Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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