IHPK1 Protein (GST Tag)

10.12.2012

Sino Biological Inc. liefert IHPK1 Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über IHPK1 Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/IHPK1-Protein-g-9980.html

Produkt-Information von IHPK1 Protein

Synonym :	IHPK1, IP6K1,KIAA0263
Protein Construction:	A DNA sequence encoding the human IHPK1(Q92551-1) (Met1-Gln441) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Source:	Human
Expression Host:	Baculovirus-Insect cells

QC Testing von IHPK1 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: IHPK1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human IHPK1 /GST chimera consists of 678 amino acids and has a calculated molecular mass of 78 kDa. The recombinant protein migrates approximately 88 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris,500mM NaCl, pH 8.0, 10%gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IHPK1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IHPK1 Protein

IHPK1 is a inositol hexaphosphate kinase (IHPK) protein. During cell death, IHPK1 activity is enhanced, and intracellular InsP7 level is augmented. The distribution of IHPK1 or another predisposing gene affected by position effect of translocation may explain the T2DM phenotype at least in this family. IHPKs belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers.

References

Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
Saiardi A. et al., 2001, J Biol Chem. 276 (42): 39179-85.
Kamimura J. et al., 2004, J Hum Genet. 49 (7): 360-5.