IGF1 / IGF-I Protein (Native)

Produkt-Information von IGF1 / IGF-I Protein

QC Testing von IGF1 / IGF-I Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: IGF1 / IGF-I protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mature form of human IGF1 consisting of 71 amino acids and has a calculated molecular mass of 7.8KDa.
Formulation	Lyophilized from 0.2μm filtered solution of 30%Acetonitrile，0.1%TFA. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IGF1 / IGF-I Protein

Verwandte Produkte & Themen von IGF1 / IGF-I Protein

Cancer>>Growth Factor & Receptor>>IGF System>>IGF-1/IGF-I

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>IGF-1/IGF-I

Beschreibung von IGF1 / IGF-I Protein

Insulin-like growth factor I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

References

1. Dull TJ. et al., 1984, Nature. 310: 777-81.
2. Bell GI. et al., 1984, Nature. 310: 775-7.
3. Cooke RM. et al., 1991, Biochemistry. 30: 5484-91.
4. Sandberg-Nordqvist A-C. et al., 1992, Brain Res Mol Brain Res. 12: 275-7.

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