ICOS Ligand / B7-H2 / ICOSLG Antikörper

28.06.2012

Produkt-Information von ICOS Ligand / B7-H2 / ICOSLG Antikörper

Immunogen	Recombinant Human ICOS Ligand / B7-H2 / ICOSLG protein (Catalog#11559-H08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	5C6B3
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 / ICOSLG (rh ICOS Ligand / B7-H2 / ICOSLG; Catalog#11559-H08H; NP_056074.1; Met 1-Ser 258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von ICOS Ligand / B7-H2 / ICOSLG Antikörper

Specificity	Human ICOS Ligand / B7-H2 / ICOSLG
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human ICOSLG in WB. Using a DAB detection system, the detection limit for Human ICOSLG is approximately 4 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von ICOS Ligand / B7-H2 / ICOSLG Antikörper

Related Areas:

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>ICOS Ligand/B7-H2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>ICOS Ligand/B7-H2/CD275

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ICOS Ligand/B7-H2	Human	ICOS Ligand/B7-H2 Protein, Recombinant	11559-H08H
ICOS Ligand/B7-H2	Mouse	ICOS Ligand/B7-H2/Fc Protein, Recombinant	50190-M03H
ICOS Ligand/B7-H2	Mouse	ICOS Ligand/B7-H2 Protein, Recombinant	50190-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ICOS Ligand/B7-H2	WB, ELISA	ICOS Ligand/B7-H2 Antibody, Rabbit PAb	11559-RP01
Human ICOS Ligand/B7-H2	WB, ELISA	ICOS Ligand/B7-H2 Antibody, Rabbit PAb (Antigen Affinity Purified)	11559-RP02
Human ICOS Ligand/B7-H2	WB	ICOS Ligand / B7-H2 / ICOSLG Antibody	11559-MM03
Human ICOS Ligand/B7-H2	ELISA	ICOS Ligand / B7-H2 / ICOSLG Antibody	11559-MM07
Mouse ICOS Ligand/B7-H2	WB, ELISA	Rabbit Polyclonal Antibody	50190-RP01
Mouse ICOS Ligand/B7-H2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50190-RP02

Hintergrund von ICOS Ligand / B7-H2 / ICOSLG Antikörper

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein. The receptor binding site on ICOSL is constituted chiefly by aromatic / hydrophobic residues.

References

Wiendl, H. et al., 2003,Brain. 126 (Pt 5): 1026-1035.
Chattopadhyay, K. J. et al., 2006, Immunol.177 (6):3920-3929.

Sino Biological Inc. liefert ICOS Ligand / B7-H2 / ICOSLG Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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