HPGD / 15-PGDH Antikörper

15.03.2012

Produkt-Information von HPGD / 15-PGDH Antikörper

Immunogen	Recombinant Mouse HPGD / 15-PGDH protein (Catalog#50531-M08E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse HPGD / 15-PGDH (rM HPGD / 15-PGDH; Catalog#50531-M08E; Q8VCC1; Met 1-Ser 269). Total IgG was purified by Protein A affinity chromatography.

HPGD / 15-PGDH Antikörper Usage Guide

Specificity	Mouse HPGD / 15-PGDH
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse HPGD in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse HPGD. The detection limit for Mouse HPGD is approximately 0.0195 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von HPGD / 15-PGDH Antikörper

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Hintergrund von HPGD / 15-PGDH Antikörper

15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor inmany species and regulate uterine contractility and cervicaldilatation. Therefore, the regulation of prostaglandin outputby PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activitypatterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR), cranioosteoarthropathy (COA),and isolated congenital nail clubbing.

References

Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
Tariq, M. et al., 2009,J Med Genet. 46 (1): 14-20.

Sino Biological Inc. liefert HPGD / 15-PGDH Antikörperr mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über HPGD / 15-PGDH Antikörper lesen Sie bitte: http://www.sinobiological.com/HPGD-15-PGDH-Antibody-g-8292.html