GMPR / GMPR1 Protein (His Tag)

30.05.2013

Sino Biological Inc. liefert GMPR / GMPR1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über GMPR / GMPR1 Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/GMPR-GMPR1-Protein-Antibody-a-6214.html

Produkt-Information von GMPR / GMPR1 Protein

Synonym	GMPR, GMPR1
Protein Construction	A DNA sequence encoding the human GMPR (Met1-Ser345) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von GMPR / GMPR1 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: GMPR protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human GMPR consists of 360 amino acids and predicts a molecular mass of 39.2 KDa. It migrates as an approximately 37 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Tris, 150mM NaCl, 40% Glycerol, 1mM DTT, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von GMPR / GMPR1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GMPR / GMPR1 Protein

GMPR, also known as GMPR1, belongs to the IMPDH/GMPR family. This family of enzymes includes IMP dehydrogenase and GMP reductase. These enzymes are involved in purine metabolism and adopt a TIM barrel structure. GMPR is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. GMPR functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

References

Waterworth DM. et al., 2010, Arterioscler Thromb Vasc Biol. 30 (11): 2264-76.
Patton GC. et al., 2011, Nat Chem Biol. 7 (12): 950-8.
Hedstrom L. 2012, Crit Rev Biochem Mol Biol. 47 (3): 250-63.