GMFB Protein (Native)

27.12.2012

Sino Biological Inc. liefert GMFB Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über GMFB Protein (Native) lesen Sie bitte: http://www.sinobiological.com/GMFB-Protein-g-10251.html

Produkt-Information von GMFB Protein

Synonym	GMFB
Protein Construction	A DNA sequence encoding the human GMFB (Met1-His142) was expressed.
Source	Human
Expression Host	E.coli

QC Testing von GMFB Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: GMFB protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human GMFB consists of 142 amino acids and predicts a molecular mass of 16.7 KDa. It migrates as an approximately 17 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, PH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von GMFB Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GMFB Protein

GMFB is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor and contains 1 ADF-H domain. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.

References

Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Zaheer S. et al., 2011, Neuroscience. 194: 227-33.
Danielsen JM. et al., 2011, Mol Cell Proteomics. 10 (3): M110.003590.