GBP-2 / GBP2 Protein (His Tag)

12.12.2012

Sino Biological Inc. liefert GBP-2 / GBP2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über GBP-2 / GBP2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/GBP-2-GBP2-Protein-g-9992.html

Produkt-Information von GBP-2 / GBP2 Protein

Synonym	GBP2
Protein Construction	A DNA sequence encoding the human GBP2 (AAH73163.1) (Met1-Cys588) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von GBP-2 / GBP2 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: GBP-2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human GBP2 consists of 599 amino acids and predicts a molecular mass of 68.3 KDa. It migrates as an approximately 62 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von GBP-2 / GBP2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GBP-2 / GBP2 Protein

GBP-2 is a member of the guanylate-binding protein (GBP) family. As GTPases induced by IFN-gamma (Interferon-inducible GTPase), GBPS are key to the protective immunity against microbial and viral pathogens. GBPS are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). GBP-2 is a GTPase that converts GTP to GDP and GMP. It binds GTP, GDP and GMP. GBP-2 hydrolyzes GTP very efficiently. GDP rather than GMP is the major reaction product. GBP-2 is induced by interferons that have antiviral effects and inhibit tumor cell proliferation.

References

Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
Wistow G. et al., 2002, Mol Vis. 8: 205-20.
Neun R et al., 1996, FEBS Lett. 390 (1): 69-72.