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| Immunogen | Recombinant Mouse FGFR1 / CD331 protein (Catalog#50186-M08H) |
| Antibody Type | Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) |
| Clone ID | 001 |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse FGFR1 / CD331 (rM FGFR1 / CD331; Catalog#50186-M08H; P16092-1; Met 1-Glu 376). |
| Specificity | Mouse FGFR1 / CD331 |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse FGFR1 in WB. Using a DAB detection system, the detection limit for Mouse FGFR1 is approximately 10 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions. |
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FGFR1. The detection limit for Mouse FGFR1 is approximately 0.039 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Fibroblast growth factor receptor 1 (FGFR1) is a member of the fibroblast growth factor receptor (FGFR) family, whose amino acid sequence is highly conserved between members throughout evolution. FGFR family members differ from one another in their ligand affinities, tissue distribution and have been implicated in a multitude of activities. FGFR1, also known as fms-related tyrosine kinase-2 (FLT2) and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein structurally consists of an extracellular region containing three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR1 is the receptor for FGF basic and also interacts with GRB14, SHB, FRS2. Defects in FGFR1 are the cause of several deseases, such as Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), as well as Pfeiffer syndrome (PF).
Sino Biological Inc. liefert FGFR1 / CD331 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über FGFR1 / CD331 Antikörper lesen Sie bitte: http:www.sinobiological.com/FGFR1-CD331-Antibody-g-9199.html
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