Erythropoietin / EPO Antikörper (Antigen Affinität reinigt)

09.03.2012

Produkt-Information von Erythropoietin / EPO Antikörper

Immunogen	Recombinant Rat Erythropoietin / EPO protein (Catalog#80055-R08B)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Rat Erythropoietin / EPO (rR Erythropoietin / EPO; Catalog#80055-R08B; P29676-1; Met 1-Arg 192). Erythropoietin / EPO specific IgG was purified by Rat Erythropoietin / EPO affinity chromatography.

Erythropoietin / EPO Antikörper Usage Guide

Specificity	Rat Erythropoietin / EPO
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat EPO in WB. Using a DAB detection system, the detection limit for Rat EPO is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat EPO. The detection limit for Rat EPO is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Erythropoietin / EPO Antikörper

Erythropoietin, also known as EPO, is a secreted protein which belongs to theEPO / TPO family. Erythropoietin / EPO is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Erythropoietin / EPO is produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. EPO is produced mainly by peritubular fibroblasts of the renal cortex. It is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver. Erythropoietin / EPO is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. Erythropoietin / EPO is the hormone that regulates red blood cell production. It plays an important role in the brain's response to neuronal injury. Erythropoietin / EPO is also involved in the wound healing process. Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation. Erythropoietin / EPO binds to the erythropoietin receptor (EPOR) on the red cell surface and activates a JAK2 cascade. EPOR is also found in a large number of tissues such as bone marrow cells and peripheral/central nerve cells, many of which activate intracellular biological pathways upon binding with EPO. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus.

References

Lin FK, et al., 1985, Proc. Natl. Acad. Sci. USA.82 (22): 7580-4.
Fisher JW, et al.,1996, British journal of haematology. 95 (1): 27-32.
Macdougall IC, et al., 2000, Semin. Nephrol.20 (4): 375-81.
Siren AL et al., 2001. Proc Natl Acad Sci USA98 (7): 4044-9.
Haroon ZA, et al.,2003, Am. J. Pathol.163 (3): 993-1000.
Jelkmann W, et al., 2007, Eur. J. Haematol.78 (3): 183-205.

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