ErbB2 / HER2 / CD340 Antikörper ( FITC )

Receptor tyrosine-protein kinase erbB-2, also known as epidermal growth factor receptor-related protein, proto-oncogene Neu, proto-oncogene c-ErbB-2, CD340 and ErbB2, is a single-pass type I membrane protein, cytoplasm protein and nucleus protein which belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. The ErbB protein family, also known as epidermal growth factor receptor (EGFR) family, is a family of four structurally related receptor tyrosine kinases (ErbB1 / EGFR, ErbB2 / HER2, ErbB3 / HER3, ErbB4 / HER4). The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: Erythroblastic Leukemia Viral Oncogene. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. Mouse ErbB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for rat ErbB2. It binds to the 5'-TCAAATTC-3' sequence in the MT-CO2 promoter and activates its transcription. ErbB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. ErbB2 cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. This receptor forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays an key role in development, cell proliferation and differentiation.

1. Yamamoto, T. et al., 1986, Nature. 319: 230-34.
2. Lai C., et al., 1991, Neuron 6: 691-704.
3. Gullick W.J., et al., 1992, EMBO J. 11: 43-48.
4. Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-201.
5. Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37.
6. Kermit, L. et al., 1999, J. Biol. Chem. 274: 5263-66.
7. Nathan J. 2001, J. Biol. Chem. 276: 42153-161.
8. Ying-Xin, Fan. et al., 2008, J. Biol. Chem. 283: 1588-96.