EphB4 Antikörper ( FITC )

Produkt-Information von EphB4 Antikörper

Usage Guide von EphB4 Antikörper

Specificity	Human EphB4
	No cross-reactivity in WB and ELISA with Human cell lysate (293 cell line)
Flow Cytometry	Flow cytometric analysis of anti-EphB4 reactivity on MCF-7 cells. Profile of anti-EphB4 reactivity on MCF-7 cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von EphB4 Antikörper

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB4

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB4

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>EphB4

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB4

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB4

Hintergrund von EphB4 Antikörper

EphB4, also known as Htk, Myk-1, is a member of the Eph subfamily of receptor tyrosine kinases (RTKs). The Ephs are divided into two classes based on their extracellular structure and ligand specificity, and the transmembrane receptor binding preferentially to ephrin-B ligands is referred to as EphB. Sharing common structure organization, all Eph receptors contain an N-terminal Ig-like domain, a cysteine-rich region and two fibronectin type III domains within the ECD, as well as the typical cytoplasmic tyrosine kinase domain. EphB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EphB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis, and tumor growth. In contrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EphB4 is associated with prostate cancer and highly malignant breast cancers, and accordingly, EphB4 has potential applications as a therapeutic candidate.

References

1. Bennett, B.D. et al., 1994, J. Biol. Chem. 269: 14211-14218.
2. Noren, N.K. et al., 2004, Proc. Natl. Acad. Sci. 101: 5583-5588.
3. Murai, K.K. et al., 2003, J. Cell. Sci. 116: 2823-2832.
4. Noren, N.K. et al., 2006, Nat. Cell. Biol. 8: 815-825.
5. Xia, G. et al., 2005, Cancer Res. 65: 4623-4632.
6. Kertesz, N. et al., 2006, Blood. 107: 2330-2338.

Sino Biological Inc. liefert EphB4 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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