EpCAM / TROP1 / CD326 Antikörper( FITC )

Produkt-Information von EpCAM / TROP1 / CD326 Antikörper

Usage Guide von EpCAM / TROP1 / CD326 Antikörper

Specificity	Human EpCAM / TROP1 / CD326
	Has cross-reactivity in ELISA with Human CD146 Human CD171 Human OPCML Human TROP2 No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Flow Cytometry	Flow cytometric analysis of anti-EpCAM (CD326) reactivity on SKBR3 cells. Profile of anti-EpCAM (CD326) reactivity on SKBR3 cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von EpCAM / TROP1 / CD326 Antikörper

Hintergrund von EpCAM / TROP1 / CD326 Antikörper

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. This protein is present in the majority of human epithelial cells and is highly expressed in gastrointestinal carcinomas. It has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. Since the cell-cell adhesion is known to play an important role in tumor progression and metastasis, the high expression of GA733-2 antigen is associated with malignant tumor development in various types of cancer lesions. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. EpCAM is being used as a target for immunotherapy treatment of human carcinomas.

References

1. Simon, B. et al., 1990, Proc. Natl. Acad. Sci. 87: 2755-2759.
2. Chong,J.M. et al., 2001, J. Biol. Chem. 276: 5804-5813.
3. Litvinov, S. V. et al., 1994, J. Cell. Biol. 125: 437-446.
4. Balzar, M. et al., 1999. J. Mol. Med. 77: 699-712.
5. Yamashita, T. et al., 2007, Cancer. Res. 67: 10831-10839.

Sino Biological Inc. liefert EpCAM / TROP1 / CD326 Antikörper( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über EpCAM / TROP1 / CD326 Antikörper( FITC ) lesen Sie bitte: http://www.sinobiological.com/EpCAM-TROP1-CD326-Antibody-g-9040.html