EpCAM / TROP-1 / TACSTD1 Antikörper

29.02.2012

Produkt-Information von EpCAM / TROP-1 / TACSTD1 Antikörper

Immunogen	Recombinant Mouse EpCAM / TROP-1 / TACSTD1 protein (Catalog#50591-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse EpCAM / TROP-1 / TACSTD1 (rM EpCAM / TROP-1 / TACSTD1; Catalog#50591-M08H; NP_032558.2; Met 1-Thr 266). Total IgG was purified by Protein A affinity chromatography.

EpCAM / TROP-1 / TACSTD1 Antikörper Usage Guide

Specificity	Mouse EpCAM / TROP-1 / TACSTD1
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse EPCAM in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse EPCAM. The detection limit for Mouse EPCAM is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von EpCAM / TROP-1 / TACSTD1 Antikörper

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type Itransmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. This protein is present in the majority of human epithelial cells and is highly expressed in gastrointestinal carcinomas. It has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. Since the cell-cell adhesion is known to play an important role in tumor progression and metastasis, the high expression of GA733-2 antigen is associated with malignant tumor development in various types of cancer lesions. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. EpCAM is being used as a target for immunotherapy treatment of human carcinomas.

References

Simon, B. et al., 1990, Proc. Natl. Acad. Sci. 87: 2755-2759.
Chong,J.M. et al., 2001, J. Biol. Chem. 276: 5804-5813.
Litvinov, S. V. et al., 1994, J. Cell. Biol. 125: 437-446.
Balzar, M. et al., 1999. J. Mol. Med. 77: 699-712.
Yamashita, T. et al., 2007, Cancer. Res. 67: 10831-10839.

Sino Biological Inc. liefert EpCAM / TROP-1 / TACSTD1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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