Mouse Meteorin / METRN Protein

24.12.2012

Sino Biological Inc. liefert Mouse Meteorin / METRN Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse Meteorin / METRN Protein lesen Sie bitte: http://www.sinobiological.com/Meteorin-METRN-Protein-g-10177.html

Produkt-Information von Meteorin / METRN Protein

Synonym	METRN, Hyrac
Protein Construction	A DNA sequence encoding the mouse METRN (Q8C1Q4-1)(Gly22-Asp291) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von Meteorin / METRN Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: Meteorin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant mouse METRN/Fc comprises 526 amino acids and has a predicted molecular mass of 58.4 kDa. The apparent molecular mass of the protein is approximately 57 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS,pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Meteorin / METRN Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Meteorin / METRN Protein

Meteorin is a novel secreted protein that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin is highly expressed in astrocytes of the brain and the retina during late embryonic and postnatal stages of development. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.

References

Martin J. et al., 2004, Nature. 432 (7020): 988-94.
Nishino J. et al., 2004, EMBO J. 23 (9): 1998-2008.
Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.