DIM1 / TXNL4A Protein (His Tag)

04.05.2012

Produkt-Information von DIM1 / TXNL4A Protein

Synonym	DIB1, DIM1, HsT161, TXNL4, U5-15kD
Protein Construction	A DNA sequence encoding the human TXNL4A (P83876) (Met 1-Tyr 142) was expressed, with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von DIM1 / TXNL4A Protein

Purity	> 94 % as determined by SDS-PAGE	SDS-PAGE: DIM1 / TXNL4A protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human TXNL4A consists of 157 amino acids and has a calculated molecular mass of 18.6KDa. It migrates as an approximately 16 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of 50mM Tris,150mM NaCl; pH8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von DIM1 / TXNL4A Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DIM1 / TXNL4A Protein Description

DIM1, also known as TXNL4A, is a member of the Dim protein family. There are two members in the Dim protein family, DIM1and Dim2. They share a common thioredoxin-like fold. These two proteins were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, DIM1 and Dim2 proteins differ in many aspects. DIM1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. DIM1 interacts with HNRPF, HNRPH2, NEDD9/HEF1 and PQBP1/NPW38. It plays an essential role in pre-mRNA splicing.

References

Zhang Y. et al., 2001, Gene. 257 (1): 33-43.
Zhang YZ. et al., 2003, Biochemistry. 42 (32): 9609-18.
Zhang YZ. et al., 2000, Physiol Genomics. 1 (3): 109-18.

Sino Biological Inc. liefert DIM1 / TXNL4A Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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