DCXR / HCR2 Protein (His Tag)

25.04.2013

Sino Biological Inc. liefert DCXR / HCR2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über DCXR / HCR2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/DCXR-HCR2-Protein-Antibody-a-5849.html

Produkt-Information von DCXR / HCR2 Protein

Synonym	DCXR
Protein Construction	A DNA sequence encoding the mature form of human DCXR (Q7Z4W1) (Met1-Cys244) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von DCXR / HCR2 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: DCXR protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human DCXR consists of 259 amino acids and predicts a molecular mass of 27.8 KDa. It migrates as an approximately 29 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 20% Glycerol, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von DCXR / HCR2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von DCXR / HCR2 Protein

DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of glucose metabolism. It may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

References

Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Pierce SB. et al., 2011, Proc Natl Acad Sci. 108 (45): 18313-7.
Udeshi ND. et al., 2012, Mol Cell Proteomics. 11 (5): 148-59.

DCXR (HCR2) related areas, pathways, and other information