Cynomolgus OLR1 / LOX1 Protein (His Tag)

19.03.2013

Sino Biological Inc. liefert Cynomolgus OLR1 / LOX1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus OLR1 / LOX1 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/OLR1-LOX1-Protein-a-2648.html

Produkt-Information von OLR1 / LOX1 Protein

Synonym	OLR1
Protein Construction	A DNA sequence encoding the cynomolgus OLR1 (G7PJT2) (Ser61-Gln273) was expressed with a polyhistide tag at the N-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von OLR1 / LOX1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: OLR1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant heterodimer of cynomolgus OLR1 comprises 233 amino acids and has a calculated molecular mass of 26.9 KDa. The apparent molecular mass of the protein is approximately 37 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von OLR1 / LOX1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von OLR1 / LOX1 Protein

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a receptor protein which belongs to the C-type lectin superfamily. Lectin-like oxidized LDL receptor-1 (LOX-1) was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX-1 is inducted by inflammatory stimuli, so LOX-1 is thought to be involved in the development of atherosclerotic lesions. It is an important cell surface receptor for the progression of atherosclerosis. LOX-1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. LOX-1 expression is also induced in smooth muscle cells in response to proinflammatory and oxidative stimuli. LOX-1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2.

References

Hinagata J. et al., 2006, Cardiovasc Res. 69 (1): 263-71.
Melan MA. et al., 1994, Plant Physiol. 105 (1): 385-393.
Saito A. et al., 2010, Acta Neurochir (Wien). 152 (4): 589-95.