Cynomolgus IL18RAP Protein

06.12.2012

Sino Biological Inc. liefert Cynomolgus IL18RAP Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus IL18RAP Protein lesen Sie bitte: http://www.sinobiological.com/IL18RAP-Protein-g-9967.html

Produkt-Information von IL18RAP Protein

Synonym	IL18RAP
Protein Construction	A DNA sequence encoding the cynomolgus IL18RAP (F7HHC1) (Met1-Arg356) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von IL18RAP Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL18RAP protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 20
Molecular Mass	The recombinant cynomolgus IL18RAP is a disulfide-linked homodimer. The reduced monomer comprises 578 amino acids and has a calculated molecular mass of 65.4 KDa.The apparent molecular mass of the protein is approximately 92 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL18RAP Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von IL18RAP Protein

Related Areas:

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL18RAP/IL-1R7/CD218b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL18RAP/IL-1R7/CD218b

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>IL18RAP/IL-1R7/CD218b

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL18RAP/IL-1R7/CD218b

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL18RAP/IL-1R7/CD218b	Human	IL18RAP/IL-1R7/CD218b/Fc Protein, Recombinant	10176-H02H
IL18RAP/IL-1R7/CD218b	Human	IL18RAP/IL-1R7/CD218b Protein, Recombinant	10176-H08H
IL18RAP	Cynomolgus	IL18RAP Protein, Recombinant	90122-C02H
IL18RAP	Cynomolgus	IL18RAP Protein, Recombinant	90122-C08H

Antibodies:

Beschreibung von IL18RAP Protein

Interleukin 18 receptor accessory protein, also known as IL18RAP, IL1R7 and CDw218b, is a single-pass type I membrane protein. It is member of the interleukin-1 receptor family. IL18RAP contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. IL18RAP is strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon. It is not expressed in any other tissue tested. IL18RAP is also strongly expressed in T-cells polarized with IL12 and specifically coexpressed with IL18R1 in Th1 cells. IL18RAP is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1, the ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18. Variants at IL18RAP have been linked to susceptibility to coeliac disease.

References

Born TL. et al., 1998, J Biol Chem. 273 (45): 29445-50.
Hillier LW. et al., 2005, Nature. 434: 724-31.
Hunt KA. et al., 2008, Nat Genet. 40 (4): 395-402.
Imami K. et al., 2008, Anal Sci. 24: 161-6.