Cynomolgus IGFBP3 Protein (His Tag)

07.01.2013

Sino Biological Inc. liefert Cynomolgus IGFBP3 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus IGFBP3 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/IGFBP3-Protein-g-10280.html

Produkt-Information von IGFBP3 Protein

Synonym	IGFBP3
Protein Construction	A DNA sequence encoding the cynomolgus IGFBP3(Gly28-Lys291) was expressed with a polyhistide tag at the N-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von IGFBP3 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IGFBP3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant heterodimer of cynomolgus IGFBP3 comprises 284 amino acids and has a calculated molecular mass of 31.1 KDa. The apparent molecular mass of the protein is approximately 41-44 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IGFBP3 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von IGFBP3 Protein

Related Areas:

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>IGFBP3

Cancer>>Cancer Biomarkers>>IGFBP3

Cancer>>Growth Factor & Receptor>>IGF System>>IGFBP3

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IGFBP3	Human	IGFBP3 Protein, Recombinant	10430-H07H
IGFBP3	Cynomolgus	IGFBP3 Protein, Recombinant	90084-C07H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IGFBP3	WB, ELISA	IGFBP3 Antibody, Mouse Monoclonal Antibody	10430-MM01
Human IGFBP3	WB, ELISA	IGFBP3 Antibody	10430-RP01
Human IGFBP3	WB, ELISA	IGFBP3 Antibody (Antigen Affinity Purified)	10430-RP02
Human IGFBP3	WB, ELISA	IGFBP3 Antibody	10430-R008

Beschreibung von IGFBP3 Protein

Insulin-like growth factor-binding proteins (IGFBPs) prolong the half-life of the IGFs, control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified. Human IGFBP3 is a widely expressed protein containing an IGFBP domain at the N-terminus and a thyroglobulin type-I domain. IGFBP3 forms a ternary complex of about 140 ~150 kDa with IGF1 or IGF2 and a glycoprotein insulin-like growth factor acid-labile subunit (ALS), thus alter the interaction of IGFs with their cell surface receptors. IGFBP3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. Studies have shown that IGFBP3 can leads to the induction of apoptosis dependent or independent of the IGF-IGF receptor axis, accordingly acts as a negative regulator of tumorigenesis and progressing in certain carcinomas. In addition, IGFBP3 also interacts with the Alzheimer's survival peptide humanin (HN), playing a role in neurological disease processes.

References

Cubbage ML. et al., 1990, J Biol Chem. 265: 12642-9.
Ikonen M. et al., 2003, Proc Natl Acad Sci. 100: 130428-47.
Kim HS. et al., 2004, Cancer Res. 64: 2229-37.
Hong J. et al., 2002, J Biol Chem. 277: 10488-97.