CRP / C-reactive Protein(Native)

20.03.2013

Sino Biological Inc. liefert CRP / C-reactive Protein(Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CRP / C-reactive Protein(Native) lesen Sie bitte: http://www.sinobiological.com/CRP-C-Reactive-Protein-Antibody-a-1270.html

Produkt-Information von CRP / C-reactive Protein

Synonym	CRP, PTX1
Protein Construction	A DNA sequence encoding the human CRP (P02741-1) (Met1-Pro224) was expressed and purified.
Source	Human
Expression Host	Human Cells

QC Testing von CRP / C-reactive Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: CRP protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 19
Molecular Mass	The recombinant human CRP consists of 206 amino acids and has a predicted molecular mass of 23 kDa. As a result of glycosylation, the apparent molecular mass of CRP is approximately 26 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris, 0.2M NaCl, 5mM CaCl2, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CRP / C-reactive Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CRP / C-reactive Protein

C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

References

Pepys MB. et al., 2003, J Clin Invest. 111 (12): 1805-12.
Thompson D. et al., 1999, Structure. 7(2): 169-77.