Complement C1s Antikörper

Sino Biological Inc. liefert Complement C1s Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Hintergrund von Complement C1s Antikörper

Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. The single-chain proenzyme C1s is processed into the active form of disulfide-linked two chains: the A chain contains multiple domains in the order of CUB1-EGF-CUB2-CCP1 -CCP2-Activation Peptide, while the B chain contains the serine protease catalytic domain. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.

References

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