CNDP2 Antikörper

27.02.2012

Produkt-Information von CNDP2 Antikörper

Immunogen	Recombinant Mouse CNDP2 protein (Catalog#50246-M08B)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse CNDP2 (rM CNDP2;Catalog#50246-M08B; NP_075638.2; Met 1-Asn 475). Total IgG was purified by Protein A affinity chromatography.

CNDP2 Antikörper Usage Guide

Specificity	Mouse CNDP2
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CNDP2 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse CNDP2. The detection limit for Mouse CNDP2 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von CNDP2 Antikörper

Cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to thepeptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Itmay be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.

References

Bakker,SJ. et al., 2008,Diabetes57 (12):e16; author reply e17.
Wanic, K. et al., 2008, Diabetes57 (9): 2547-51.
McDonough,CW. et al., 2009,Hum Genet126 (2): 265-75.
Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.

Sino Biological Inc. liefert CNDP2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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