CEACAM1 / CD66a Antikörper (Antigen Affinität reinigt)

09.03.2012

Produkt-Information CEACAM1 / CD66a Antikörper

Immunogen	Recombinant Mouse CEACAM1 / CD66a protein (Catalog#50571-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse CEACAM1 / CD66a (rM CEACAM1 / CD66a; Catalog#50571-M08H; NP_001034274.1; Met 1-Gly 428). CEACAM1 / CD66a specific IgG was purified by Mouse CEACAM1 / CD66a affinity chromatography.

CEACAM1 / CD66a Antikörper Usage Guide

Specificity	Mouse CEACAM1 / CD66a
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CEACAM1 in WB. Using a DAB detection system, the detection limit for Mouse CEACAM1 is approximately 2 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CEACAM1. The detection limit for Mouse CEACAM1 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von CEACAM1 / CD66a Antikörper

Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1), also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. There are two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, and seven CEACAM has been identified in humans including type I transmembrane proteins (CEACAM-1, 3, 4) and GPI-linked molecules (CEACAM-5-8). The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

References

Hinoda, Y. et al., 1988, Proc. Natl. Acad. Sci. USA. 85:6959-63.
Zalzali, H. et al., 2008, Oncogene. 27: 7131-8.
Erqun, S. et al., 2000, Mol. Cell. 5: 311-20.
Oliveira-Ferrer, L. et al., 2004, Cancer. Res. 64: 8932-8.

Sino Biological Inc. liefert CEACAM1 / CD66a Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CEACAM1 / CD66a Antikörper (Antigen Affinität reinigt) lesen Sie bitte: http://www.sinobiological.com/CEACAM1-CD66a-Antibody-g-8252.html